Miss Sherlock depicts consulting detective Sara Sherlock Shelly Futaba (Yuko Takeuchi) solving various mysteries in modern-day Tokyo. Sherlock is assisted by her flatmate, Dr. Wato Tachibana (Shihori Kanjiya), a doctor who has recently returned from volunteering medical aid in Syria. Because of Sherlock's keen observational and deduction skills, she is frequently asked by Inspector Gentaro Reimon of the Metropolitan Police to help with cases. Although the series depicts a variety of crimes and perpetrators, Sherlock must deal with the secret organization, Stella Maris, who is behind some of the crimes they solve. Other recurring characters include Kimi Hatano, the landlady where Sherlock lives, and Kento Futaba, the Prime Minister Secretary and Sherlock's older brother.