Last Seen Alive 2022 Chase centers on Will Spann Butler, who is driving his soon to be ex wife Lisa Alexander to her parents home when she mysteriously disappears without a trace during a stop at a gas station A frantic Will engages the local police and Lisas parents in a desperate attempt to find her, but as time passes and suspicion falls on him, he must take matters into his own hands, delving into the towns criminal underbelly while running from the authorities in a race against time to find Lisa